Bioorganic and Medicinal Chemistry Letters p. 1107 - 1112 (1998)
Update date:2022-08-02
Topics:
Parmee, Emma R.
Ok, Hyun O.
Candelore, Mari R.
Tota, Laurie
Deng, Liping
Strader, Catherine D.
Wyvratt, Matthew J.
Fisher, Michael H.
Weber, Ann E.
A study of 4-acylaminobenzenesulfonamides in a cloned human β3 adrenergic receptor assay resulted in the discovery of n-hexylurea, L- 755,507 (22). This 0.43 nM β3 agonist, which is > 440-fold selective over both β1 and β2 binding, is among the most potent human β3 agonists reported to date.
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