Discovery of L-755,507: A subnanomolar human β3 adrenergic receptor agonist

DOI: 10.1016/S0960-894X(98)00170-X

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1107 - 1112 (1998)

Update date:2022-08-02

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Authors:

Parmee, Emma R.

Ok, Hyun O.

Candelore, Mari R.

Tota, Laurie

Deng, Liping

Strader, Catherine D.

Wyvratt, Matthew J.

Fisher, Michael H.

Weber, Ann E.

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Article abstract of DOI:10.1016/S0960-894X(98)00170-X

A study of 4-acylaminobenzenesulfonamides in a cloned human β₃ adrenergic receptor assay resulted in the discovery of n-hexylurea, L- 755,507 (22). This 0.43 nM β₃ agonist, which is > 440-fold selective over both β₁ and β₂ binding, is among the most potent human β₃ agonists reported to date.

Full text of DOI:10.1016/S0960-894X(98)00170-X

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