An Efficient and Versatile Method for the Preparation of α-Keto Acid Derivatives from Terminal Alkenes

Article abstract of DOI:10.1016/0040-4039(95)01638-X

Ozonolysis of terminal alkenes followed by reacting with a preheated mixture of CH2Br2-Et2NH affords α-substituted acroleins, which can be converted to α-keto acid derivatives in three steps, under very mild reaction conditions.