An Efficient and Versatile Method for the Preparation of α-Keto Acid Derivatives from Terminal Alkenes

DOI: 10.1016/0040-4039(95)01638-X

Source and publish data:

Tetrahedron Letters p. 7693 - 7696 (1995)

Update date:2022-08-05

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Authors:

Hon, Yung-Son

Lin, Wei-Chih

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Article abstract of DOI:10.1016/0040-4039(95)01638-X

Ozonolysis of terminal alkenes followed by reacting with a preheated mixture of CH2Br2-Et2NH affords α-substituted acroleins, which can be converted to α-keto acid derivatives in three steps, under very mild reaction conditions.

Full text of DOI:10.1016/0040-4039(95)01638-X

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