
Tetrahedron Letters p. 8225 - 8228 (1994)
Update date:2022-08-03
Topics: Stereocontrolled Synthesis Synthetic study Swinholide A
Nakata, Tadashi
Komatsu, Toshiya
Nagasawa, Kazuo
Yamada, Haruo
Takahashi, Takashi
The C11-C23 segment 4 of swinholide A (1) was synthesized stereoselectively starting from (S)-malic acid via double nitroaldol reaction under high pressure and differentiation of the left and right parts of the symmetric compound 10 as the key steps.
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