Tetrahedron Letters p. 5599 - 5602 (1989)
Update date:2022-08-03
Topics:
Linz, Guenter
Weetman, John
Hady, A. F. Abdel
Helmchen, Guenter
The first synthesis of enantiomerically pure cyclosarkomycin, a stable, crystaline precursor of the antitumor agent sarkomycin is reported.Key steps are an asymmetric Diels-Alder reaction of the (E)-3-bromoacrylate of (R)-pantolactone and introduction of oxygen funtionality via elimination/β-addition.The synthesis of cyclosarkomycin was accomplished in 9 steps
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Doi:10.1021/ja01308a043
(1935)Doi:10.1002/ardp.19903230207
(1990)Doi:10.1021/jm00169a001
(1990)Doi:10.1039/c0cc04280c
(2011)Doi:10.1021/jo200067y
(2011)Doi:10.1016/S0040-4039(00)70717-9
(1989)
