Cathepsin B-sensitive dipeptide prodrugs. 2. Models of anticancer drugs paclitaxel (taxol), mitomycin C and doxorubicin

DOI: 10.1016/S0960-894X(98)00610-6

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 3347 - 3352 (1998)

Update date:2022-08-04

Topics:

Authors:

Dubowchik, Gene M.

Mosure, Kathleen

Knipe, Jay O.

Firestone, Raymond A.

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Article abstract of DOI:10.1016/S0960-894X(98)00610-6

Substrates containing doxorubicin (DOX), paclitaxel (taxol), and mitomycin C (MMC) attached to the cathepsin B-sensitive dipeptide Phe-Lys via a self-immolative spacer were prepared as model compounds for internalizing anticancer immunoconjugates. Catheps

Full text of DOI:10.1016/S0960-894X(98)00610-6

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