Total Synthesis of (-)-Cephalotaxine

DOI: 10.1021/jo00106a023

Source and publish data:

Journal of Organic Chemistry p. 115 - 119 (1995)

Update date:2022-08-04

Topics:

Authors:

Isono, Naohiro

Mori, Miwako

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Article abstract of DOI:10.1021/jo00106a023

Total synthesis of (-)-cephalotaxine was achieved from D-(+)-proline by a short sequence of steps.The key intermediate, 1-azaspiro<4.4>nonane, was prepared from vinyl iodide, using stannyl anion generated from Me3SiSnBu3 and CsF, in good yield.

Full text of DOI:10.1021/jo00106a023

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