Synthesis and conformational analysis of 2'-deoxy-2'-(3-methoxybenzamido)adenosine, a rational-designed inhibitor of trypanosomal glyceraldehyde phosphate dehydrogenase (GAPDH)

DOI: 10.1002/hlca.19940770306

Source and publish data:

Helvetica Chimica Acta p. 631 - 644 (1994)

Update date:2022-08-05

Topics:

Authors:

Van Calenbergh

Van Den Eeckhout

Herdewijn

De Bruyn

Verlinde

Hol Hol

Callens Callens

Van Aerschot

Rozenski

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Article abstract of DOI:10.1002/hlca.19940770306

A series of 2'-benzamido-2'-deoxyadenosine analogues were synthesized in an effort to find new lead structures for the treatment of sleeping sickness. The 2'-deoxy-2'-(3-methoxybenzamido)adenosine (1h) was proved to be a selective inhibitor of the parasit

Full text of DOI:10.1002/hlca.19940770306

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