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6-Substituted quinolines as RORγt inverse agonists

DOI: 10.1016/j.bmcl.2017.10.027

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 5277 - 5283 (2017)

Update date:2022-08-03

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Authors:

Barbay, J. KentBarbay, J. Kent

Cummings, Maxwell D.Cummings, Maxwell D.

Abad, MartaAbad, Marta

Castro, GlendaCastro, Glenda

Kreutter, Kevin D.Kreutter, Kevin D.

Kummer, David A.Kummer, David A.

Maharoof, UmarMaharoof, Umar

Milligan, CynthiaMilligan, Cynthia

Nishimura, RachelNishimura, Rachel

Pierce, JoanPierce, Joan

Schalk-Hihi, CelineSchalk-Hihi, Celine

Spurlino, JohnSpurlino, John

Tanis, Virginia M.Tanis, Virginia M.

Urbanski, MaudUrbanski, Maud

Venkatesan, HariharanVenkatesan, Hariharan

Wang, AihuaWang, Aihua

Woods, CraigWoods, Craig

Wolin, RonaldWolin, Ronald

Xue, XiaohuaXue, Xiaohua

Edwards, James P.Edwards, James P.

Fourie, Anne M.Fourie, Anne M.

Leonard, KristiLeonard, Kristi

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Article abstract of DOI:10.1016/j.bmcl.2017.10.027

We identified 6-substituted quinolines as modulators of the retinoic acid receptor-related orphan receptor gamma t (RORγt). The synthesis of this class of RORγt modulators is reported, and optimization of the substituents at the quinoline 6-position that

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Full text of DOI:10.1016/j.bmcl.2017.10.027

Products guided by the article

Product name:(2,4-dichloro-3-phenylquinolin-6-yl)(phenyl)(pyridin-4-yl)methanol

Cas No:1600563-44-7

1600563-44-7

R&D Labs maybe for 1600563-44-7

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