Total Synthesis of Alternaric Acid

DOI: 10.1016/S0040-4039(00)77605-2

Source and publish data:

Tetrahedron Letters p. 2327 - 2330 (1993)

Update date:2022-07-30

Topics: Characterization functional group interconversions Biological testing Retrosynthetic analysis Stereochemistry Control Purification and Isolation Ring Formation Protection and Functional Group Manipulation Assembly of Fragments Late-Stage Modifications

Authors:

Tabuchi, Hiroyasu

Hamamoto, Taisuke

Miki, Shokyo

Tejima, Tsuyoshi

Ichihara, Akitami

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Article abstract of DOI:10.1016/S0040-4039(00)77605-2

A total synthesis of alternaric acid (1) has been achieved.Key reactions include the Julia olefination of tertiary aldehyde 4 and phenylsulfone 5, and novel one-pot construction of 3-acyl-4-hydroxy-5,6-dihydropyrone via Fries type rearrangement of O-enola

Full text of DOI:10.1016/S0040-4039(00)77605-2

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