Photochemical Nickel-Catalyzed Reductive Migratory Cross-Coupling of Alkyl Bromides with Aryl Bromides

DOI: 10.1021/acs.orglett.8b00413

Source and publish data:

Organic Letters p. 1880 - 1883 (2018)

Update date:2022-07-29

Topics:

Authors:

Peng, Long

Li, Zheqi

Yin, Guoyin

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Article abstract of DOI:10.1021/acs.orglett.8b00413

A novel method to access 1,1-diarylalkanes from readily available, nonactivated alkyl bromides and aryl bromides via visible-light-driven nickel and iridium dual catalysis, wherein diisopropylamine (ⁱPr₂NH) is used as the terminal stoichiometric reductant, is reported. Both primary and secondary alkyl bromides can be successfully transformed into the migratory benzylic arylation products with good selectivity. Additionally, this method showcases tolerance toward a wide array of functional groups and the presence of bases.

Full text of DOI:10.1021/acs.orglett.8b00413

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