Synthesis of resolution of 2-arylalkyl-2-(tetrazol-5-yl)-N-arylalkyl-carboxamides. A new class of chiral sterically hindered tetrazole derivatives

Article abstract of DOI:10.1002/jhet.5570320125

Chiral, racemic 2-arylalkyl-2-(tetrazol-5-yl)-N-arylalkylcarboxamides 3 were conveniently prepared from ethyl cyanoacetate in four steps. The synthetic methodology developed is a facile way of introducing bulky substituents into a peptide-like framework,