Asymmetric synthesis of the antibiotic (+)-thiamphenicol using cis-N-(p-toluenesulfinyl)aziridine 2-carboxylic acids

DOI: 10.1016/S0040-4039(00)78334-1

Source and publish data:

Tetrahedron Letters p. 7525 - 7528 (1994)

Update date:2022-08-04

Topics:

Authors:

Davis, Franklin A.

Zhou, Ping

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0040-4039(00)78334-1

A concise, highly efficient asymmetric synthesis of aminopropanediol (1R,2R)-(-)-3, precursor to the broad spectrum antibiotics thiamphenicol/florfenicol 1/2, was prepared in two steps from cis-aziridine 2-carboxylic acid (2S,3S)-(-)-5.

Full text of DOI:10.1016/S0040-4039(00)78334-1

Products guided by the article

Product name:cis-(S_S,2S,3S)-(+)-N-(p-toluenesulfinyl)-2-carbomethoxy-3-(p-methylthiophenyl)aziridine

Cas No:160751-26-8

R&D Labs maybe for 160751-26-8

SNC | GOOD FORTUNE

Contact:0086-22-2822 1962 / 2822 1963

Address:B-808, No. 1, North-South Street, Hexi District,
Sichuan Sangao Biochemical Co., Ltd

Contact:+86-28-84874233

Address:19F, Bldg.2, Shudu Center, Tianfu 2nd St., Hi-tech zone, Chengdu 610041, Sichuan Province, China.
shanghai Tauto Biotech Co., Ltd

website:http://www.tautobiotech.com/en/index.htm

Contact:+86-21-51320588 ext. 8025

Address:No. 326, Aidisheng Rd , Zhangjiang Hi-tech Park, Shanghai , P.R.CHINA
ShangHai Ruiyi Medical Technology Co.,Ltd.

Contact:+86-21-54718086

Address:No951 Jianchuan RD，Minhang District
Nanjing Chemipioneer Pharma&Tech Co.,Ltd

website:http://www.chemipioneer.com.cn

Contact:+86-25-52685700

Address:Room 305，A Block，Biological-Medicine Building，Business Start-up Center，Xin-ke 1st Road, High-tech development zone，Nanjing city，Jiangsu Province, China

Relevant to this article

Kinetic analysis of the formation and decay of a non-heme ferric hydroperoxide species susceptible to O-O bond homolysis

Doi:10.1021/ic5003786
(2014)
3-substituted-N-(4-hydroxynaphthalen-1-yl)arylsulfonamides as a novel class of selective Mcl-1 inhibitors: Structure-based design, synthesis, SAR, and biological evaluation

Doi:10.1021/jm500010b
(2014)
Secondary alkene insertion and precision chain-walking: A new route to semicrystalline polyethylene from α-olefins by combining two rare catalytic events

Doi:10.1021/ja502130w
(2014)
Synthesis of modified pyrimidine nucleosides via Vorbrüggen-type N-glycosylation catalyzed by 2-methyl-5-phenylbenzoxazolium perchlorate

Doi:10.1016/j.tet.2014.03.013
(2014)
Synthesis of electron-deficient dienes bearing a chromonyl moiety via the reaction of 3-formylchromones with ylidenemalononitriles and ethyl α-cyano-β-methylcinnamate Dedicated to Professor Oleg N. Chupakhin on his 80th birthday

Doi:10.1016/j.tet.2014.03.105
(2014)
Total synthesis of (+)-kopsihainanine A

Doi:10.1039/c4cc01843e
(2014)

Article Doi