Asymmetric synthesis of the antibiotic (+)-thiamphenicol using cis-N-(p-toluenesulfinyl)aziridine 2-carboxylic acids

DOI: 10.1016/S0040-4039(00)78334-1

Source and publish data:

Tetrahedron Letters p. 7525 - 7528 (1994)

Update date:2022-08-04

Topics:

Authors:

Davis, Franklin A.

Zhou, Ping

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Article abstract of DOI:10.1016/S0040-4039(00)78334-1

A concise, highly efficient asymmetric synthesis of aminopropanediol (1R,2R)-(-)-3, precursor to the broad spectrum antibiotics thiamphenicol/florfenicol 1/2, was prepared in two steps from cis-aziridine 2-carboxylic acid (2S,3S)-(-)-5.

Full text of DOI:10.1016/S0040-4039(00)78334-1

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Product name:cis-(S_S,2S,3S)-(+)-N-(p-toluenesulfinyl)-2-carbomethoxy-3-(p-methylthiophenyl)aziridine

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