Bioorganic and Medicinal Chemistry Letters p. 1935 - 1940 (1998)
Update date:2022-09-26
Topics:
Jacobs, Robert T.
Shenvi, Ashok B.
Mauger, Russell C.
Ulatowski, Terrance G.
Aharony, David
Buckner, Carl K.
A series of 4-alkylpiperidine derivatives related to the potent neurokinin-2 (NK2) receptor antagonist SR-48968 (1) is described. Simple aliphatic derivatives were found to be poorly active, but appropriate placement of an alcohol functional group afforded compounds that were of similar activity to 1. Several representatives in this series, such as the 4- (1-hydroxy-1-ethylpropyl)piperidine (14), were found to exhibit oral activity in a model of labored abdominal breathing in guinea pigs. These results expand the latitude of substituents available in this region of this series of NK2 receptor antagonists.
View Morewebsite:http://www.vanzpharm.com/en/index.html
Contact:86-27-84492310
Address:FANHU INDUSTRY PARK
Nanjing Raise Pharmatech Co., Ltd
website:http://www.raisechem.com
Contact:+86-25-58649566
Address:B381,No.606,Ningliu Road,Jiangbei New Area,Nanjing,Jiangsu Province,China
Changzhou Qidi Chemical Co., Ltd
website:http://www.czqdhg.com/
Contact:86-519-83382137
Address:128-1-16# HuaYuan Street,Hutang Town,Wujin District,Changzhou City,P.R.China.
Hebei Tianxiang Biological & Pharmaceutical Co., Ltd
Contact:86-0312-6615158
Address:No 42 fazhan street qingyuan county
Contact:+86-571-86025531 / 86024803
Address:1218-24 Guangyin Mansion,42 Fengqi East Road
Doi:10.1039/c39940002081
(1994)Doi:10.1021/ja502238a
(2014)Doi:10.1002/anie.201311245
(2014)Doi:10.1002/recl.19941130603
(1994)Doi:10.1055/s-0033-1340220
(2014)Doi:10.1021/np500260z
(2014)
