Organic Letters p. 2147 - 2152 (2021)
Update date:2022-08-02
Topics: Ligands Reaction Conditions Palladium catalyst Base Steric and Electronic Effects
Wang, Mei-Ling
Xu, Hui
Li, Han-Yuan
Ma, Biao
Wang, Zhen-Yu
Wang, Xing
Dai, Hui-Xiong
Mizoroki-Heck reaction of unstrained aryl ketone with acrylate/styrene is accomplished via palladium-catalyzed ligand-promoted C-C bond cleavage. Various (hetero)aryl ketones are compatible in the reaction, affording the alkene product in good to excellent yields. Further applications in the late-stage olefination of some drugs, natural products, and fragrance-derived aryl ketones demonstrate the synthetic utility of this protocol. By employing ketone as both the directing group and the leaving group, 1,2-bifunctionalization is achieved via sequential ortho-C-H alkylation/ipso-Heck olefination.
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Doi:10.1002/anie.201310864
(2014)Doi:10.1016/j.tetlet.2014.04.009
(2014)Doi:10.1039/c7ob00654c
(2017)Doi:10.1039/c4cc01831a
(2014)Doi:10.1039/c3dt53471e
(2014)Doi:10.1021/ja502310r
(2014)