Tetrahedron Letters p. 373 - 376 (1995)
Update date:2022-08-04
Topics: Synthesis Antagonist Analog Nonpeptide Potent
Miller, William H.
Newlander, Kenneth A.
Eggleston, Drake S.
Haltiwanger, R. Curtis
The preparation of the 2-benzazepine derivative 3 as an analog of the potent, nonpeplide GPIIb/IIIa antagonist 2 is reported. The synthetic route employs as key steps a Heck arylation of dimethyl itaconate and a selective cyclization to form the aryl-fuse
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