Conversion of 1-benzyl-4-aminotetrahydropyridine-3-carboxylic acid methyl ester to antithrombotic pyrido[4,3-d]pyrimidine-2,4-diones and to (2-oxotetrahydropyrimidin-4-ylidene)acetic acid methyl esters

Article abstract of DOI:10.1002/jhet.5570310649

6-Benzyl-3-methyl-5,6,7,8-tetrahydro-1H-pyrido[4,3-d]pyrimidine-2,4-di one 2, a representative of new antithrombotic compounds with favourable cerebral and peripheral effects has been synthesized from enamine 1 in good yield by two methods. The thermal fu