Stereoselective formation of (E)-β-alkoxy acrylates from fischer carbene complexes and chelated amino acid ester enolates

Article abstract of DOI:10.1055/s-0033-1340496

Chelated amino acid ester enolates react with alkyl Fischer carbene complexes via nucleophilic attack on the electrophilic carbene center. Subsequent elimination of the metal fragment and trifluoroacetamide results in the formation of β-alkoxy-α,β-unsaturated esters in a highly E-stereoselective fashion. Georg Thieme Verlag Stuttgart. New York.