Bioorganic and Medicinal Chemistry Letters p. 2099 - 2104 (1997)
Update date:2022-08-04
Topics:
Asari, Tohru
Ishikawa, Shigetaka
Sasaki, Toshiki
Katada, Jun
Hayashi, Yoshio
Harada, Takeo
Yano, Mako
Yasuda, Emiko
Uno, Isao
Ojima, Iwao
The synthetic and structure-activity relationship (SAR) studies of new non-peptide GPIIb/IIIa antagonists (1a-f and 3) were conducted by replacing one amide bond of NSL-95300 (2) with an (E)-double bond or an enone group. NSL-95315 (1a) and NSL-95317 (3) showed the inhibitory activity for collagen-induced human platelet aggregation with IC50 values of 0.25 μM and 0.21 μM, respectively.
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Doi:10.1016/S0031-9422(97)00116-7
(1997)Doi:10.1016/S0960-894X(02)01070-3
(2003)Doi:10.1055/s-1997-1524
(1997)Doi:10.1016/S0020-1693(97)05694-6
(1997)Doi:10.1007/s11172-017-1764-1
(2017)Doi:10.1039/a703112b
(1997)
