Development of new non-peptide GPIIb-IIIa antagnosts, NSL-95315 and NSL-95317, isosteres of NSL-95300

DOI: 10.1016/S0960-894X(97)00366-1

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2099 - 2104 (1997)

Update date:2022-08-04

Topics:

Authors:

Asari, Tohru

Ishikawa, Shigetaka

Sasaki, Toshiki

Katada, Jun

Hayashi, Yoshio

Harada, Takeo

Yano, Mako

Yasuda, Emiko

Uno, Isao

Ojima, Iwao

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0960-894X(97)00366-1

The synthetic and structure-activity relationship (SAR) studies of new non-peptide GPIIb/IIIa antagonists (1a-f and 3) were conducted by replacing one amide bond of NSL-95300 (2) with an (E)-double bond or an enone group. NSL-95315 (1a) and NSL-95317 (3) showed the inhibitory activity for collagen-induced human platelet aggregation with IC₅₀ values of 0.25 μM and 0.21 μM, respectively.

Full text of DOI:10.1016/S0960-894X(97)00366-1

Products guided by the article

Product name:(E)-5-(4-Cyano-phenyl)-2,2-dimethyl-5-oxo-pent-3-enoic acid

Cas No:196202-78-5

R&D Labs maybe for 196202-78-5

SHANGHAI BIOSUNDRUG CO.,LTD.

Contact:86-21-34622192，13917187091，21-34622765

Address:No. 500 Caobao Road Shanghai P.R China
Shangyu Sanhechemicals Co.,LTD.

Contact:86-0571-56696839

Address:Num.2952,Nanhuan Road,Binjiang District,Hangzhou,China
Hangzhou jls Flame Retardants Chemical Co.,Ltd

Contact:+86-571-87250387/87250386

Address:MOGANSHAN RODA 1418# SHANGCHENG INDUSTRIAL PARK
Arromax Pharmatech Co.,Ltd

website:http://www.arromax.com

Contact:+86-0512-62959601 skype:aimmezhang

Address:Suite 401, Bldg A3, 218 Xinghu St.Suzhou Industrial Park 215123, P.R. China
GLD peptide scientific lnc.

Contact:21-7631221 15884421033

Address:326 Science and technology,Shanghai,China

Relevant to this article

Mono-tetrahydrofuran ring acetogenins from Goniothalamus donnaiensis

Doi:10.1016/S0031-9422(97)00116-7
(1997)
Discovery of novel neuronal voltage-dependent calcium channel blockers based on emopamil left hand as a bioactive template

Doi:10.1016/S0960-894X(02)01070-3
(2003)
An Alternative Synthesis of Both Enantiomers of trans-3,4-Bis(benzyloxy)cyclopentanone

Doi:10.1055/s-1997-1524
(1997)
A novel octa-substituted iridium carbonyl derivative containing the dehydrogenated dppf ligand (dppf=Fe(C₅H₄PPh₂)₂): Synthesis and crystal structure of [H₄Ir₄(CO)₄{Fe(C₅H ₃PPh₂)(C₅H₄P(Ph)C₆H ₄)}₂]

Doi:10.1016/S0020-1693(97)05694-6
(1997)
Synthesis 5-(pyrazolin-3-ylmethylidene)-2-thiohydantoins and 2-alkylsulfanyl-5-(pyrazolin-3-ylmethylidene)-3,5-dihydro-4H-imidazol-4-ones

Doi:10.1007/s11172-017-1764-1
(2017)
Synthesis of a series of new, highly electrophilic, monocyclopentadienyltitanium olefin polymerization initiators

Doi:10.1039/a703112b
(1997)

Article Doi