Discovery of 4-(4-aminopyrazolo[1,5-a][1,3,5]triazin-8-yl)benzamides as novel, highly potent and selective, orally bioavailable inhibitors of Tyrosine Threonine Kinase, TTK

DOI: 10.1016/j.bmcl.2016.06.021

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 3562 - 3566 (2016)

Update date:2022-08-03

Topics:

Authors:

Laufer, Radoslaw

Li, Sze-Wan

Liu, Yong

Ng, Grace

Lang, Yunhui

Feher, Miklos

Brokx, Richard

Beletskaya, Irina

Hodgson, Richard

Mao, Guodong

Plotnikova, Olga

Awrey, Donald E.

Mason, Jacqueline M.

Wei, Xin

Lin, Dan Chi-Chia

Che, Yi Che, Yi

Kiarash, Reza

Madeira, Brian

Fletcher, Graham C.

Mak, Tak W.

Bray, Mark R.

Pauls, Henry W.

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Article abstract of DOI:10.1016/j.bmcl.2016.06.021

TTK/Mps1 is a key kinase controlling progression of cell division via participation in the mitotic spindle assembly checkpoint and is overexpressed in a number of human cancers. Herein we report the discovery of 4-(4-aminopyrazolo[1,5-a][1,3,5]triazin-8-y

Full text of DOI:10.1016/j.bmcl.2016.06.021

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Product name:8-bromo-N-(4-methoxybenzyl)-2-(methylthio)-N-(2-morpholinoethyl)pyrazolo[1,5-a][1,3,5] triazin-4-amine

Cas No:1610679-58-7

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