Synthesis of symmetrical pseudopeptides as potential inhibitors of the human immunodeficiency virus-1 protease

Article abstract of DOI:10.1016/0223-5234(94)90025-6

It is demonstrated that HIV-1 protease is essential for the assembly and infectivity of the acquired immunodeficiency syndrome (AIDS) virus. This protease is an aspartyl protease with a 2-fold symmetry axis. Potential inhibitors were synthesized and consi