Helvetica Chimica Acta p. 2142 - 2146 (1994)
Update date:2022-08-03
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Jefford
McNultyu
L-Aspartic acid by successive N-tosylation, anhydride formation, and reduction was converted into (3S)-3-(tosylamino)butano-4-lactone (4). Electrophilic methylation of 4, subsequent iodo-esterification and nucleophilic methylation, followed by saponification and deprotection, gave (2S,3R)-3-amino-2-methylpentanoic acid (2) with an ee of > 99%in seven steps and in an overall yield of 34%.
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Doi:10.1002/ejoc.201700504
(2017)Doi:10.1039/c4ra02429j
(2014)Doi:10.1021/jo500812d
(2014)Doi:10.1007/BF00906001
()Doi:10.1039/c8dt01717d
(2018)Doi:10.3987/COM-94-S(B)77
(1994)
