Palladium-catalyzed direct mono-α-arylation of α-fluoroketones with aryl halides or phenyl triflate

Article abstract of DOI:10.1016/j.jfluchem.2016.09.016

A palladium catalyzed Negishi-type α-arylation of α-fluoroketones with electron-rich and electron-deficient aryl halides or phenyl triflate has been developed. This direct mono-α-arylation method generate a variety of ternary α-aryl-α-monofluoroketones easily in good to excellent yields using XPhos as ligand and Cs₂CO₃as mild base.