The synthesis of (-)-4-methyl-8-chloro-trans-1,23,4,4a,5,6,10b-octahydrobenzo-[f]-quinolin-3-one -[3-14C] (LY300502-14C]) via a circuitous route

Article abstract of DOI:10.1002/jlcr.2580341004

The synthesis of the C-14 labeled isotopomer of LY300502, a potent 5α-reductase inhibitor has been accomplished in four radiochemical steps. The route involves the synthesis of LY300502-[¹⁴C] from LY300502 via a circuitous route; the label was introduced with ethyl chloroformate-[carbonyl-¹⁴C]