An efficient and simple synthesis of 3,4,5,6-tetrahydro-2H-1,2-oxazines by sodium cyanoborohydride reduction of 5,6-dihydro-4H-1,2-oxazines

Article abstract of DOI:10.1055/s-1994-25636

3,4,5,6-Tetrahydro-2H-1,2-oxazines are prepared by reduction of the corresponding 5,6-dihydro-4H-1,2-oxazines with sodium cyanoborohydride as the reducing agent in acetic acid. This reaction gives the 3,5-disubstituted compounds 2a-c, 2f-g, and 5a,b with