New Leupeptin Analogues: Synthesis and Inhibition Data

DOI: 10.1021/jm00163a014

Source and publish data:

Journal of Medicinal Chemistry p. 86 - 93 (1990)

Update date:2022-08-04

Topics:

Authors:

McConnell, Rose M.

Barnes, George E.

Hoyng, Charles F.

Gunn, J. Martin

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00163a014

Syntheses of several tripeptide analogues of leupeptin containing C-terminal argininal, lysinal, or ornithinal units are presented.The synthetic analogues were tested as inhibitors of trypsin, plasmin, and kallikrein. (Benzyloxycarbonyl)-L-leucyl-L-leucyl

Full text of DOI:10.1021/jm00163a014

Products guided by the article

Product name:N^α-(benzyloxycarbonyl)-N^ε-(tert-butoxycarbonyl)-L-lysinal semicarbazone

Cas No:122314-18-5

R&D Labs maybe for 122314-18-5

Xian Changyue Biological Technology Co., Ltd.

website:https://www.xachangyue.com/

Contact:+86-029-88211911

Address:Keji Road NO.70
SPE Chemicals Co.,Ltd

Contact:

Address:ROOM 1715, No#345 Jin Xiang Road, Pudong District
Nanjing Habo Medical Technology Co., Ltd.

Contact:025－85769882

Address:No.108. Ganjiabian east. Qixia District .Nanjing
Jinan Hongfangde Pharmatech Co.,Ltd

Contact:86-531-88870908

Address:F Bldg. West Unit North Area of Univ. Tech. Garden Xinyu Rd. Jinan New & High Tech Industry Development Zone Shandong, China
Nanjing Fubang Chemical Co.,Ltd

Contact:+86-25-83179199

Address:5F,Tianzheng international plaza,No399 Zhongyang Road ,Nanjing China

Relevant to this article

Enantioselective iridium catalyzed α-alkylation of azlactones by a tandem asymmetric allylic alkylation/aza-Cope rearrangement

Doi:10.1039/c9cc01450k
(2019)
SYNTHESIS OF (Z)-PREDOMINANT α,β-UNSATURATED NITRILES FROM ENONE CYANOHYDRIN DIETHYL PHOSPHATES: APPLICATION TO THE SYNTHESIS OF (+/-)-NUCIFERAL, (+/-)-(E)-AND -(Z)-NUCIFEROL, AND (+/-)-MANICONE

Doi:10.1039/P19880003163
(1988)
Metal-Free Direct Trifluoromethylthiolation of Aromatic Compounds Using Triptycenyl Sulfide Catalyst

Doi:10.1021/acs.orglett.1c00727
(2021)
Synthesis and reactivity of 3-amino-1H-pyrazolo[4,3-c]pyridin-4(5H)-ones: development of a novel kinase-focussed library

Doi:10.1016/j.tet.2010.02.047
(2010)
Cyanoacetanilides intermediates in heterocyclic synthesis. Part 5: Preparation of hitherto unknown 5-aminopyrazole and pyrazolo[1,5-a]pyrimidine derivatives containing sulfamoyl moiety

Doi:10.1002/jccs.200900154
(2009)
Syntheses of C-5-spirocyclic C-glycoside SGLT2 inhibitors

Doi:10.1016/j.tetlet.2010.02.024
(2010)

Article Doi