Synthesis, properties, and pharmacokinetic studies of N2-phenylguanine derivatives as inhibitors of herpes simplex virus thymidine kinases

DOI: 10.1021/jm00001a010

Source and publish data:

Journal of Medicinal Chemistry p. 49 - 57 (1995)

Update date:2022-07-30

Topics: Synthesis Inhibitory activity Properties Structure-Activity Relationship (SAR) Pharmacokinetics Toxicity and Safety Formulation

Authors:

Maga Maga

Focher Focher

Smith Smith

Spadari Spadari

Gambino Gambino

Wright Wright

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Article abstract of DOI:10.1021/jm00001a010

Two series of selective inhibitors of herpes simplex virus types 1 and 2 (HSV1,2) thymidine kinases (TK) have been developed as potential treatment of recurrent virus infections. Among compounds related to the potent base analog N²-[m-(trifluor

Full text of DOI:10.1021/jm00001a010

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