Synthesis, properties, and pharmacokinetic studies of N2-phenylguanine derivatives as inhibitors of herpes simplex virus thymidine kinases

DOI: 10.1021/jm00001a010

Source and publish data:

Journal of Medicinal Chemistry p. 49 - 57 (1995)

Update date:2022-07-30

Topics: Synthesis Inhibitory activity Properties Structure-Activity Relationship (SAR) Pharmacokinetics Toxicity and Safety Formulation

Authors:

Maga Maga

Focher Focher

Smith Smith

Spadari Spadari

Gambino Gambino

Wright Wright

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00001a010

Two series of selective inhibitors of herpes simplex virus types 1 and 2 (HSV1,2) thymidine kinases (TK) have been developed as potential treatment of recurrent virus infections. Among compounds related to the potent base analog N²-[m-(trifluor

Full text of DOI:10.1021/jm00001a010

Products guided by the article

Product name:9H-Purine-9-ethanol, 6-chloro-2-[[3-(trifluoromethyl)phenyl]amino]-, acetate (ester)

Cas No:161363-26-4

R&D Labs maybe for 161363-26-4

Puyang Willing Chemicals Co.,Ltd.

Contact:86-393-4840366

Address:Puyang Henan China
Puyang Willing Chemicals Co.,Ltd.

Contact:86-393-4840366

Address:Puyang Henan China
Jiaxing Barton Chemicals

website:http://www.chinabarton.com

Contact:+86-573-82719618

Address:No. 162 Fumin Road, Honghe Town,
CHANGYI CITY FENGRUN FINE CHEMICAL CO.,LTD

website:http://www.fengrunhuagong.com

Contact:+86-536-7869976

Address:Changyi Coastal Economic Development Zone
Shuanghe Bio-Technology Limited(expird)

Contact:+86-571-61710758,18968016640

Address:Jinqiao north road 916# Fuyang

Relevant to this article

Synthesis, enantiomeric separation and docking studies of spiropiperidine analogues as ligands of the nociceptin/orphanin FQ receptor

Doi:10.1039/c4md00082j
(2014)
Synthesis, isomerism, and hypotensive activity of thiethane-containing hydrazones of uracilylacetic acid

Doi:10.1134/S1068162014030108
(2014)
Synthesis of VIP-lipopeptide using a new linker to modify liposomes: Towards the development of a drug delivery system for active targeting

Doi:10.1248/cpb.c13-00518
(2013)
Doi:10.1021/jo01270a036
(1968)
Synthesis and biological activity of carboxyphenylquinolines and related compounds as new potent retinoids. Retinobenzoic acids. VII

Doi:10.1248/cpb.42.2575
(1994)
Simple and efficient synthesis of tetrahydro-β-carbolines via the Pictet-Spengler reaction in 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP)

Doi:10.1039/c4ra03628j
(2014)

Article Doi