Highly stereocontrolled and concise asymmetric synthesis of the β-lactam framework via a TCC method

DOI: 10.1016/S0040-4039(00)74424-8

Source and publish data:

Tetrahedron Letters p. 8425 - 8428 (1994)

Update date:2022-08-03

Topics:

Authors:

Asao, Naoki

Shimada, Takashi

Tsukada, Naofumi

Yamamoto, Yoshinori

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Article abstract of DOI:10.1016/S0040-4039(00)74424-8

The conjugate addition of LSA 1 to t-butyl (4S)-4-(trityl)oxy-2-pentenoate 2d followed by aldol condensation with acetaldehyde produces a key intermediate 3 to β-lactam derivatives as a single diastereoisomer in 77% yield.

Full text of DOI:10.1016/S0040-4039(00)74424-8

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