Efficient synthesis of uracil-derived hexa- and tetrahydropyrido[2,3-d] pyrimidines

Article abstract of DOI:10.1002/ejoc.201300683

A reaction of 6-amino-1,3-dimethyluracil with 3-(hetero)aroylacrylic acids and their methyl esters leads to hexahydropyrido[2,3-d]pyrimidine-5-carboxylic acids or the corresponding methyl esters in high to excellent yields. One-pot oxidation of the acid d