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Cisplatin Analogues with Sulfur Donor Ligands. (Ethylenediamine)platinum(II) Complexes with Ligands possessing a Sulfinyl or Sulfanyl Group linked to an Anionic Oxygen Donor Atom. Reactivity and Cytotoxicity

DOI: 10.1039/DT9950000579

Source and publish data:

Journal of the Chemical Society, Dalton Transactions p. 579 - 586 (1995)

Update date:2022-09-26

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Authors:

Pasini, AlessandroPasini, Alessandro

Perego, PaolaPerego, Paola

Balconi, MassimoBalconi, Massimo

Lupatini, MauroLupatini, Mauro

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Article abstract of DOI:10.1039/DT9950000579

Complexes of formula NO3, where en = ethylenediamine and L is a ligand in which a methylsulfinyl or methylsulfanyl group is linked to a carboxylate or phenolate moiety, have been synthesized and characterized by spectroscopic techniques.The ligand L is chelated to Pt via the sulfur and anionic oxygen atoms.The reactivities of these complexes towards nucleophiles have been investigated by 1H NMR spectroscopy; GMP is more reactive than Cl(-).The Pt-O bonds react more readily than the Pt-S bonds and, depending on the nature of L and Nu, the reactions either stop at the monosubstituted complex (with L monodentate and co-ordinated to Pt via the sulfur atom), or yield .The complex with L = 2-(methylsulfanyl)phenolate is unreactive.The stable monosubstituted products have been characterized.There is little correlation between the rates and the modes of reactivity of complex NO3 towards GMP and their cytotoxicities against the human ovarian carcinoma A2780 cell line.

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Product name:[PtCl(ethylenediamine)(2-(methylsulfanyl)benzoato)]

Cas No:162048-65-9

162048-65-9

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