3'-C-Phosphonates as Nucleotides Analogues Synthesis Starting from Original C-Phosphonosugars (in ribo- and deoxyribo- series)

Article abstract of DOI:10.1016/S0040-4020(01)85564-2

3-C-phosphonosugars were synthetised starting from 2-deoxy-D-ribose and α-D-xylofuranose via the Pudovic rection followed by reduction.Their condensation with nucleobases (thymine and adenine) gave original 3'-C-phosphononucleosides in ribo- and 2-deoxyribo- series, with a stereocontrol of the reactions.Key words: 3-C-phosphonosugar, 3'-C-phosphononucleoside, Pudovic reaction, α-hydroxyphosphonate