Bioorganic and Medicinal Chemistry Letters p. 1665 - 1670 (1997)
Update date:2022-07-30
Topics:
Lin, Yang-I
Bitha, Panayota
Sakya, Subas M.
Li, Zhong
Lang Jr., Stanley A.
Yang, Youjun
Bhachech, Niraja
Weiss, William J.
Petersen, Peter J.
Jacobus, Nilda V.
Bush, Karen
Testa, Raymond T.
Peptidic prodrugs of the five most active aminomethyl-THF β- methylcarbapenems were synthesized. Of these, only L-amino acid derivatives from la demonstrated an improved oral activity. These results indicate that the L-amino acid derivatives from la are orally absorbed most likely through the dipeptide and tripeptide transport mechanism.
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