Peptidic prodrugs of novel aminomethyl-THF 1β-methylcarbapenems

Article abstract of DOI:10.1016/S0960-894X(97)00281-3

Peptidic prodrugs of the five most active aminomethyl-THF β- methylcarbapenems were synthesized. Of these, only L-amino acid derivatives from la demonstrated an improved oral activity. These results indicate that the L-amino acid derivatives from la are orally absorbed most likely through the dipeptide and tripeptide transport mechanism.