Enantioselective Total Synthesis of Doliculide, a Potent Cytotoxic Cyclodepsipeptide of Marine Origin and Structure-Cytotoxicity Relationships of Synthetic Doliculide Congeners

DOI: 10.1016/S0040-4020(01)81206-0

Source and publish data:

Tetrahedron p. 12853 - 12882 (1994)

Update date:2022-08-05

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Authors:

Ishiwata, Hiroyuki

Sone, Hiroki

Kigoshi, Hideo

Yamada, Kiyoyuki

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Article abstract of DOI:10.1016/S0040-4020(01)81206-0

The total synthesis of doliculide (1), a potent cytotoxic cyclodepsipeptide from the Japanese sea hare Dolabella auricularia, has been achieved.The key step of the synthesis is the construction of the sereogenic centers of a 15-carbon polyketide-derived d

Full text of DOI:10.1016/S0040-4020(01)81206-0

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