Formal [3+2] cycloaddition of 1-cyanocyclopropane 1-ester with pyridine, quinoline or isoquinoline: A general and efficient strategy for construction of cyanoindolizine skeletons

Article abstract of DOI:10.1039/c4cc03267e

An efficient and straightforward synthetic protocol has been developed for the preparation of cyanoindolizine derivatives via a cycloaddition reaction between 1-cyanocyclopropane 1-ester and pyridine or benzopyridine for the generation of a wide range of structurally interesting and pharmacologically significant compounds. This journal is the Partner Organisations 2014.