Bioorganic and Medicinal Chemistry Letters p. 115 - 120 (1996)
Update date:2022-08-05
Topics:
Arvanitis, Argyrios G.
Scholfield, Everett L.
Grigoriadis, Dimitri
Heytler, Peter G.
Bowdle, Jack
Chorvat, Robert J.
A series of alkylbenzylethers of substituted hydroquinone analogs of 4-(3-chlorophenyl methyloxy)-phenoxybutyronitrile I, and alcohol II were synthesized as monoamine oxidase (MAO) inhibitors. Incorporation of electron-withdrawing groups on the hydroquinone afforded compounds with higher levels of activity and selectivity than I or II for MAO B inhibition.
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