Alkylbenzyl ethers of hydroquinones as monoamine oxidase B inhibitors

Article abstract of DOI:10.1016/0960-894X(95)00561-7

A series of alkylbenzylethers of substituted hydroquinone analogs of 4-(3-chlorophenyl methyloxy)-phenoxybutyronitrile I, and alcohol II were synthesized as monoamine oxidase (MAO) inhibitors. Incorporation of electron-withdrawing groups on the hydroquinone afforded compounds with higher levels of activity and selectivity than I or II for MAO B inhibition.