Alkylbenzyl ethers of hydroquinones as monoamine oxidase B inhibitors

DOI: 10.1016/0960-894X(95)00561-7

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 115 - 120 (1996)

Update date:2022-08-05

Topics:

Authors:

Arvanitis, Argyrios G.

Scholfield, Everett L.

Grigoriadis, Dimitri

Heytler, Peter G.

Bowdle, Jack

Chorvat, Robert J.

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Article abstract of DOI:10.1016/0960-894X(95)00561-7

A series of alkylbenzylethers of substituted hydroquinone analogs of 4-(3-chlorophenyl methyloxy)-phenoxybutyronitrile I, and alcohol II were synthesized as monoamine oxidase (MAO) inhibitors. Incorporation of electron-withdrawing groups on the hydroquinone afforded compounds with higher levels of activity and selectivity than I or II for MAO B inhibition.

Full text of DOI:10.1016/0960-894X(95)00561-7

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