Dalton Transactions
Paper
the starting material as monitored by TLC. Then the reaction
mixture was evaporated in a vacuum, CH2Cl2 (10 mL × 3) was
added to the reaction mixture and the catalyst was filtered for
the next cycle of reaction. The combined CH2Cl2 solution was
removed by evaporation in a vacuum and was then subjected
to silica gel column chromatography; the one-pot three-com-
ponent aza-Friedel–Crafts product (21a) was obtained, white
solid, 235 mg, isolated yield 72%. Aldehydes (5) and indoles
(19) and the nucleophile N,N-dialkylaniline (20) are commer-
cially available.
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Acknowledgements
This work was supported by the NSFC (21273068, 21172061,
21373003, 21003040), the NSF of Hunan Province (11JJ5009,
14JJ7027), and the JSPS fellowship (P12035). The authors
thank Profs. J. Otera, and A. Orita (Okayama University of
Science) for the helpful discussions. S. Yin and R. Qiu thank
Profs. N. Kambe (Osaka University), L. B. Han (AIST), C. T. Au
and W. Y. Wong (HKBU) for helpful discussion. The authors 10 U. Thewalt and H. P. Klein, Z. Kristallogr., 1980, 153, 307.
thank Prof. S. Fukuzumi (Osaka University) for ESR analysis.
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Dalton Trans., 2014, 43, 11696–11708 | 11707