First total synthesis of (-)-auranomide C and its derivatives

Article abstract of DOI:10.1055/s-0033-1338558

The first total synthesis of (-)-auranomide C has been achieved. The short synthetic strategy involves a reductive dehydrocyclization and the nucleophilic ring opening of a fused γ-lactam. The route allows for ease in synthesizing diverse derivatives in the side chain of the natural product.