Total synthesis of Taxol. 4. The final stages and completion of the synthesis

DOI: 10.1021/ja00107a009

Source and publish data:

Journal of the American Chemical Society p. 653 - 659 (1995)

Update date:2022-08-04

Topics:

Authors:

Nicolaou

Ueno Ueno

Liu Liu

Nantermet

Yang Yang

Renaud Renaud

Paulvannan

Chadha Chadha

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Article abstract of DOI:10.1021/ja00107a009

The total synthesis of (-)-Taxol has been achieved. Functional group manipulation of diol 2 provided the ABC ring system with the correct C9-keto, C10-acetyloxy functionality. Careful optimization allowed the oxidation of the C5-C6 alkene in 4 at C5 via a

Full text of DOI:10.1021/ja00107a009

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