A Novel Synthesis of Methyl 5-Substituted Thiazole-4-carboxylates Using 3-Bromo-2-isocyanoacrylates (BICA)

DOI: 10.1016/0040-4039(94)02186-F

Source and publish data:

Tetrahedron Letters p. 257 - 260 (1995)

Update date:2022-09-26

Topics: Synthesis Experimental

Authors:

Yamada, Masaki

Fukui, Toshio

Nunami, Ken-ichi

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Article abstract of DOI:10.1016/0040-4039(94)02186-F

A novel synthetic method for methyl 5-substituted thiazole-4-carboxylates (5) by the reaction of methyl 3-substituted 3-bromo-2-isocyanoacrylates (BICA) (1) with hydrogen sulfide in the presence of triethylamine in N,N-dimethylformamide was explored, and

Full text of DOI:10.1016/0040-4039(94)02186-F

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