Asymmetric synthesis. XXXV1. Synthesis of 2-methyl 5-substituted substituted piperidines from chiral non-racemic lactams

DOI: 10.1016/0040-4039(94)02435-E

Source and publish data:

Tetrahedron Letters p. 1035 - 1038 (1995)

Update date:2022-08-02

Topics: Optimization Cyclization Purification and Isolation Analysis and Characterization

Authors:

Varea, Teresa

Dufour, Monique

Micouin, Laurent

Riche, Claude

Chiaroni, Angele

Quirion, Jean-Charles

Husson, Henri-Philippe

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Article abstract of DOI:10.1016/0040-4039(94)02435-E

A series of 2-methyl-5-substituted piperidines in enantiomerically pure form has been synthesized from lactam 3a. The stereospecific alkylation involved a rigid amide enolate.

Full text of DOI:10.1016/0040-4039(94)02435-E

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