Structure-guided evolution of a 2-phenyl-4-carboxyquinoline chemotype into PPARα selective agonists: New leads for oculovascular conditions

DOI: 10.1016/j.bmcl.2018.03.010

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2717 - 2722 (2018)

Update date:2022-08-05

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Authors:

Dou, Xiao-Zheng

Nath, Dinesh

Shin, Younghwa

Ma, Jian-Xing

Duerfeldt, Adam S.

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Article abstract of DOI:10.1016/j.bmcl.2018.03.010

Small molecule agonism of PPARα represents a promising new avenue for the development of non-invasive treatments for oculovascular diseases like diabetic retinopathy and age-related macular degeneration. Herein we report initial structure–activity relatio

Full text of DOI:10.1016/j.bmcl.2018.03.010

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