Asymmetric synthesis of tetrahydroquinolines through a [3+2] cycloaddition controlled by dienamine catalysis

DOI: 10.1002/chem.201402089

Source and publish data:

Chemistry - A European Journal p. 6592 - 6596 (2014)

Update date:2022-07-29

Topics:

Authors:

Li, Wenjun

Wei, Jia

Jia, Qianfa

Du, Zhiyun

Zhang, Kun

Wang, Jian

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Article abstract of DOI:10.1002/chem.201402089

A dienamine-mediated enantioselective 1,3-dipolar cycloaddition catalyzed by a chiral prolinol silyl ether catalyst has been developed. Removal of the benzamide group of the intermediates could furnish chiral C-1 substituted tetrahydroisoquinolines (see scheme) in high yields and excellent stereoselectivities.

Full text of DOI:10.1002/chem.201402089

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