Tetrahedron Letters p. 7193 - 7196 (1994)
Update date:2022-08-03
Topics:
Vinod, Thottumkara K.
The synthesis of the isosteric phosphonate substrate analogue inhibitor 2 and the isopolar difluoromethylenephosphonate inhibitor 3 for phosphatidylinositol-specific phospholipase C (PI-PLC) from Bacillus cereus is described. The key step involved a trichloroacetonitrile mediated condensation between the inositol derivative 8 and the corresponding phosphonic acids 16 and 18 to establish the central P-O bond in these inhibitors.
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