Single Step Stereospecific Transformation of 2-Phenylthio Secondary Amides into (Z)-3-Chloro-2-Phenylthio Acrylamides

Article abstract of DOI:10.1016/0040-4039(94)02288-M

α-Phenylthio secondary propanamides 1a-e are converted stereospecifically on treatment with NCS to the analogous (Z)-α-phenylthio-β-chloro propenamides 2a-e.Extension to longer chain secondary amide derivatives 1f-g is also possible, albeit less efficient