Synthesis and biological activity of new 3-hydroxy-3-methylglutaryl-CoA synthase inhibitors: 3-Oxetanones with a side chain mimicking the extended structure of 1233A

DOI: 10.1248/cpb.42.2097

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 2097 - 2107 (1994)

Update date:2022-07-30

Topics:

Authors:

Hashizume

Ito Ito

Morikawa

Kanaya Kanaya

Nagashima

Usui Usui

Tomoda Tomoda

Sunazuka

Kumagai Kumagai

Omura Omura

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Article abstract of DOI:10.1248/cpb.42.2097

Structural analogs of 1233A, a microbial metabolite inhibiting 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) synthase, were designed and synthesized. The 2-oxetanone moiety was left intact. All analogs prepared were tested for inhibition of HMG-CoA synt

Full text of DOI:10.1248/cpb.42.2097

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