Synthesis and biological activity of new 3-hydroxy-3-methylglutaryl-CoA synthase inhibitors: 3-Oxetanones with a side chain mimicking the extended structure of 1233A

DOI: 10.1248/cpb.42.2097

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 2097 - 2107 (1994)

Update date:2022-07-30

Topics:

Authors:

Hashizume

Ito Ito

Morikawa

Kanaya Kanaya

Nagashima

Usui Usui

Tomoda Tomoda

Sunazuka

Kumagai Kumagai

Omura Omura

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1248/cpb.42.2097

Structural analogs of 1233A, a microbial metabolite inhibiting 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) synthase, were designed and synthesized. The 2-oxetanone moiety was left intact. All analogs prepared were tested for inhibition of HMG-CoA synt

Full text of DOI:10.1248/cpb.42.2097

NII-Electronic Library Service

Products guided by the article

Product name:Isophthalic acid 1-{3-[3-(3-methoxycarbonyl-benzoylamino)-phenyl]-propyl} ester 3-methyl ester

Cas No:162471-98-9

R&D Labs maybe for 162471-98-9

WUXI HONOR SHINE CHEMICAL CO.,LTD

Contact:+86-510-83593312

Address:No.1699 Huishan avenue,Huishan district,Wuxi ,Jiangsu,China,214177.(Wuxi Huishan Ecomonic Develop Zone )
AURORA CHEMICAL CO., LTD

Contact:86-532-68629711 13780605697

Address:NO 220 YANAN 3 ROAD,(POST ADMINISTRATION BUILDING),QINGDAO,CHINA
A.M FOOD CHEMICAL CO., LIMITED

Contact:86-531-87100375

Address:20Floor，Bblock，1Building，pharma-valley，Jinan，China
Laohekou Jinghong Chemical Co.,Ltd

Contact:+86-0710-3702747

Address:163.East，Huagong Road，Laohekou
Neworld Chemical Co., Ltd Shanghai(expird)

Contact:+86-21-62202658

Address:11F, Blvd 2, No. 1969 PuXing Rd, Shanghai

Relevant to this article

4-functionally substituted 3-hetarylpyrazoles: XX. Synthesis of derivatives of 5-(pyrasol-4-yl)-1,2,4-triazole and 3-(pyrazol-4-yl)-1,2,4-triazolo[3,4-c] [1,4]oxazine

Doi:10.1134/S107042801302019X
()
Discovery of allosteric modulators of factor XIa by targeting hydrophobic domains adjacent to its heparin-binding site

Doi:10.1021/jm301757v
(2013)
Living-like helix-sense-selective polymerization of an achiral substituted acetylene having bulky substituents

Doi:10.1016/j.polymer.2013.02.009
(2013)
3'-Azido-3', 5'-dideoxythymidine-5'-methylphosphonic Acid Diphosphate: Synthesis and HIV-1 Reverse Transcriptase Inhibition

Doi:10.1021/jm00095a014
(1992)
Thiophthalides, a Novel Class of Arene-annulating Agents: Synthesis of Polynuclear Hydroaromatic Compounds

Doi:10.1039/c39920000821
(1992)
Total synthesis of (-)-lycoposerramine-S

Doi:10.1002/anie.201206863
()

Article Doi