A β-Lactam Framework as a β-Alanyl Dication Equivalent: New Synthesis of α-Amino Acid N-carboxy Anhydrides (NCAs) Derived from β-Substituted Alanines

DOI: 10.1039/c39940001505

Source and publish data:

Journal of the Chemical Society. Chemical communications p. 1505 - 1508 (1994)

Update date:2022-07-29

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Authors:

Palomo, Claudio

Aizpurua, Jesus M.

Ganboa, Inaki

Maneiro, Elena

Odriozola, Beatriz

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Article abstract of DOI:10.1039/c39940001505

Optically pure 4-formyl-3-hydroxy β-lactams are transformed into 4-methylaryl and 4-(2-ethylaryl) derivatives and converted into β-substituted alanine-derived NCAs through oxidation and Baeyer-Villiger rearrangement of the resulting α-keto β-lactams.

Full text of DOI:10.1039/c39940001505

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