Synthesis and dual antagonistic activity against thromboxane A2 and leukotriene D4 of [4-[1-(benzenesulfonamido)alkyl]phenyl]alkanoic acid derivatives

DOI: 10.1248/cpb.45.849

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 849 - 862 (1997)

Update date:2022-08-05

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Authors:

Sakurai, Shunichiro

Ogawa, Nobuo

Onogi, Yasuyo

Takeshita, Makoto

Takahashi, Hiromi

Ohashi, Tetsuo

Kato, Ken-Ichi

Yasuda, Shingo

Kato, Hideo

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Article abstract of DOI:10.1248/cpb.45.849

In order to find new antiasthmatic agents with dual antagonistic activity against thromboxane A₂ (TXA₂) and leukotriene D₄ (LTD₄) receptors, synthesis and pharmacological evaluation of various [4-[1- (benzenesulfonamido)-alkyl]phenyl]alkanoic acid derivatives were undertaken. TXA₂ and LTD₄ antagonistic activities in vitro were evaluated by measuring the inhibitory effects on U-46619-induced contraction of guinea-pig trachea and LTD₄-induced contraction of guinea-pig ileum and trachea. Several compounds showed satisfactory dual antagonistic activities, and their effect (after oral administration) on LTD₄-induced bronchoconstriction in guinea- pig in vivo was examined. The results demonstrated that both 4-[4-[1-(4- chlorobenzenesulfonamido)hexyl]phenyl]butyric acid (12e) and 4-[4[1-(4- chlorobenzenesulfonamido)-5-methylhexyl]phenyl]butyric acid (12m) possessed good anti-LTD, activities. Compounds 12e and 12m were then evaluated for other related pharmacological effects involving the arachidonic acid cascade. These compounds appear to be hybrid eicosanoids antagonists having antagonistic activity against contraction of guinea-pig trachea induced by prostaglandin D₂ (PGD₂) and PGF(2α), as well as TXA₂ and LTD₄ antagonistic activities.

Full text of DOI:10.1248/cpb.45.849

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