Neuromediator analogs: Synthesis of cis (2R,3S) and trans (2S,3S)-2,3-piperidine dicarboxylic acids from (2S)-2-phenylglycinol

Article abstract of DOI:10.1016/0040-4039(95)00088-T

The cis and trans isomers of 2,3-piperidine dicarboxylic acids were obtained in enantiopure forms from the same chiral inductor: 2-phenylglycinol. This synthesis was mainly based on a δ-lactam formation via Stille's aza-annulation/hydrogenation procedure