Chemical and Pharmaceutical Bulletin p. 2254 - 2258 (1996)
Update date:2022-08-05
Topics:
Saeki, Ken-Ichi
Tomomitsu, Masato
Kawazoe, Yutaka
Momota, Kunitaka
Kimoto, Hiroshi
Thirteen kinds of fluorinated derivatives of benzo[h]quinoline and benzo[f]qninoline were synthesized by means of the Schiemann reaction or Skraup reaction, or by an electrolytic method. The synthesized derivatives carry one or two fluorine atoms at the bay-region, the K-region, and/or on the pyridine moiety of the molecules. These compounds can be used as models to examine the effect upon genotoxicity of fluorine substitution at appropriate sites on aromatic rings. Physicochemical and spectroscopic data of the fluorinated derivatives are given.
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