Serial incorporation of a monovalent GalNAc phosphoramidite unit into hepatocyte-targeting antisense oligonucleotides

DOI: 10.1016/j.bmc.2015.11.036

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Bioorganic and Medicinal Chemistry p. 26 - 32 (2016)

Update date:2022-08-02

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Authors:

Yamamoto, Tsuyoshi

Sawamura, Motoki

Wada, Fumito

Harada-Shiba, Mariko

Obika, Satoshi

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Article abstract of DOI:10.1016/j.bmc.2015.11.036

The targeting of abundant hepatic asialoglycoprotein receptors (ASGPR) with trivalent N-acetylgalactosamine (GalNAc) is a reliable strategy for efficiently delivering antisense oligonucleotides (ASOs) to the liver. We here experimentally demonstrate the h

Full text of DOI:10.1016/j.bmc.2015.11.036

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