Pd/C-catalyzed synthesis of isoquinolones through C-H Activation

Article abstract of DOI:10.1002/cctc.201403059

The direct synthesis of isoquinolones from benzamides and alkynes through C-H activation was developed by using Pd/C as a heterogeneous catalyst without a ligand under mild conditions. A variety of isoquinolones were obtained in good yields with excellent regioselectivities. The Pd/C catalyst could be recycled three times without a significant decrease in the activity (yields as high as 85). Activation complete: The direct synthesis of isoquinolones from benzamides and alkynes through C-H activation is developed by using Pd/C as a heterogeneous catalyst. The Pd/C catalyst can be recycled three times without a significant decrease in the activity.